Recent years have witnessed a surge of interest on response generation for neural conversation systems. Most existing models are implemented by following the Encoder-Decoder framework and operate sentences of conversations at word-level. The word-level model is suffering from the Unknown Words Issue and the Preference Issue, which seriously impact the quality of generated responses, for example, generated responses may become irrelevant or too general (i.e. safe responses). To address these issues, this paper proposes a hybrid-level Encoder-Decoder model (HL-EncDec), which not only utilizes the word-level features but also character-level features. We conduct several experiments to evaluate HL-EncDec on a Chinese corpus, experimental results show our model significantly outperforms other non-word-level models in automatic metrics and human annotations and is able to generate more informative responses. We also conduct experiments with a small-scale English dataset to show the generalization ability.